Aug 11 2021
A research group of Professor KAWACHI Hiroshi and Associate Professor FUKUSUMI Yoshiyasu of the Department of Cell Biology in the Kidney Research Center, Niigata University Graduate School of Medical and Dental Sciences, elucidated the molecular linking structure for maintaining the barrier function of the renal glomerular epithelial cell’s slit diaphragm, which is responsible for proteinuria, which proteins in the blood have leaked into the urine, and clarified the mechanism by which the linking structure collapses and proteinuria develops. Many unknown areas about the proteinuria onset mechanism exist; no effective therapeutic drugs have yet been developed. This research, published in the American Journal of Pathology on July 1, 2021, is expected to contribute to developing new therapy for proteinuria.
Journal: American Journal of Pathology
Title: Nephrin–Ephrin-B1–Na+/H+ Exchanger Regulatory Factor 2–Ezrin–Actin Axis Is Critical in Podocyte Injury
Authors: Yoshiyasu Fukusumi, Hidenori Yasuda, Ying Zhang, Hiroshi Kawachi
DOI: 10.1016/j.ajpath.2021.04.004
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