Development of "a novel cell therapeutic approach using peripheral blood mononuclear cells" for ischemic stroke
November 18, 2019
A group of researchers consisting of, among others, Specially Appointed Assistant Professor Masahiro Hatakeyama, Associate Professor Masato Kanazawa, graduate student Itaru Ninomiya, and Professor Osamu Onodera, Department of Neurology, Brain Research Institute, Niigata University, and Professor Takayoshi Shimohata, Department of Neurology, Gifu University Graduate School of Medicine, for the first time found that mononuclear cells*, which are present in the peripheral blood and have roles to play in the pathological conditions following stroke, activate tissue repair capabilities through simple oxygen-glucose deprivation without the use of drug. Cerebral ischemic rats administrated these cells were shown to have significant improvements in sequelae. These findings may potentially lead to a novel therapy for ischemic stroke.
The results of the research on this "A novel therapeutic approach using peripheral blood mononuclear cells preconditioned by oxygen-glucose deprivation for ischemic stroke” was published in Scientific Reports at 7 pm on Thursday, November 14, 2019 (JST).
* Mononuclear cells: A content of leukocytes in the blood; normally involved in inflammation.
Publication Details
Title: A novel therapeutic approach using peripheral blood mononuclear cells preconditioned by oxygen-glucose deprivation
Journal: Scientific Reports
Authors: Masahiro Hatakeyama, Masato Kanazawa, Itaru Ninomiya, Kaoru Omae, Yasuko Kimura, Tetsuya Takahashi, Osamu Onodera, Masanori Fukushima, and Takayoshi Shimohata
DOI: 10.1038/s41598-019-53418-5
More 篮球比分直播
-
Prospective study on clinical utility of plasma p-Tau217 and other biomarkers in Japanese memory clinics using the LUMIPULSE platform
Research results
-
Hidden Acid Imbalance in Kidney Disease Raises Red Flags
Research results
-
Evaluation of plasma p-tau217 biomarkers in detecting amyloid pathology and predicting cognitive outcomes: Observations from Japanese Alzheimer's disease neuroimaging initiative cohort
Research results
-
From surface to depth: 3D imaging traces vascular amyloid spread in the human brain
Research results