May 26 2022
The research group led by Assistant Professor HIYOSHI Takumi, Associate Professor DOMON Hisanori and Professor TERAO Yutaka of the Graduate School of Medical and Dental Sciences (Dentistry), Niigata University discovered the mechanisms that proteolytic enzymes, known to increase in the periodontal tissue, aggravate periodontitis. Furthermore, the group revealed that proteolytic enzymes inhibitor has potential as a therapeutic strategy for the treatment of periodontitis. The research results were published in Scientific Reports on May 17, 2022.
Journal: Scientific Reports
Title: Neutrophil elastase aggravates periodontitis by disrupting gingival epithelial barrier via cleaving cell adhesion molecules
Authors: Takumi Hiyoshi, Hisanori Domon, Tomoki Maekawa, Hikaru Tamura, Toshihito Isono, Satoru Hirayama, Karin Sasagawa, Fumio Takizawa, Koichi Tabeta, Yutaka Terao
DOI: 10.1038/s41598-022-12358-3
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