May 16 2019

A group including Niigata University (Associate Professor Hiroyuki Nakai, Faculty of Agriculture, and Graduate Students, Graduate School of Science and Technology) and Tokyo University of Science (Professor Hayao Taguchi and Junior Associate Professor Masahiro Nakajima, Department of Applied Biological Science, Faculty of Science and Technology) isolated and identified a new eukaryotic endo-β-1,2-Glucanase (SGL) that hydrolyzes β-1,2-glucans, rare polysaccharides in nature. The SGL does not belong to any glycoside hydrolase families so far known, based on its amino acid sequence, function, and 3D structure. Also, its reaction mechanism differs from those of known glycoside hydrolases.

Publication Details

Title: Identification, characterization and structural analyses of a fungal endo-β-1,2-glucanase reveal a new glycoside hydrolase family
Journal: The Journal of Biological Chemistry
Authors: Nobukiyo Tanaka, Masahiro Nakajima, Megumi Narukawa-Nara, Hiroki Matsunaga, Shinji Kamisuki, Hiroki Aramasa, Yuta Takahashi, Naohisa Sugimoto, Koichi Abe, Tohru Terada, Akimasa Miyanaga, Tetsuro Yamashita, Fumio Sugawara, Takashi Kamakura, Shiro Komba, Hiroyuki Nakai and Hayao Taguchi
DOI: 10.1074/jbc.RA118.007087